Unived CurQ10

Why CurQ10

Unived’s CurQ10 harnesses 306mg of CoQ10 – a natural, trans-isomeric CoQ10 which is bio-identical to the CoQ10 found in the body. CurQ10 also contains 10mg of Piperine to optimize the bio-availability and bio-absorption of CoQ10. The dosage of CoQ10 in CurQ10 has been optimized to deliver its powerful antioxidant, anti-inflammatory, heart protection, and anti-ageing.

CurQ10 also contains 100mg of standardized phytochemical extracts of Curcumin. Curcumin, the active ingredient in Curcuma longa, has been extensively documented for its analgesic effect against inflammation arising from a wide range of conditions. It is also reported to possess chemo-protective, cardiac-protective, and anti-ageing uses.[1]

For the first time in India, Unived’s CurQ10 brings together these potent natural healing agents in one synergistic formulation to offer a wide-spectrum of therapeutic advantages.

What is CurQ10

“Imagine if the key to disease prevention was as close as your kitchen shelf…” – John. C. Martin, LE Magazine, September 2001[2]

Curcuma longa, a widely used spice and coloring agent in South Asia has been hailed for its multifaceted healing properties. Amongst the volatile oils of Curcuma longa, curcumin is the most effective and comprehensively researched for its superior anti-inflammatory mechanism which has been proven to be more efficacious and safer than traditionally used NSAIDs. Curcumin has also shown tremendous potential in aiding digestion, immune function, and combating oxidative damage to cells.[3]

CoQ10 or Ubiquinone is one of the most widely found molecules in our body, and is an essential component of most cells because of its role in energy generation.[4] CoQ10 is also attributed with significant heart-protective and antioxidant uses.[5] Despite its wide availability in the body, Coenzyme Q10 levels deplete with age. The levels of CoQ10 are also depleted in immune-compromised patients like those suffering from cholesterol lowering drug users, and smokers. Dietary sources of CoQ10 are limited and must be consumed in unsustainable quantities, thus making supplementation essential for maintaining healthy levels of CoQ10 in the body for normal heart function and energy-dependent processes.[5]

Unived’s CurQ10 brings together curcumin and CoQ10 in a breakthrough formulation that has been carefully optimized to deliver the anti-inflammatory, antioxidant, anti-ageing, and heart protection, attributes of these versatile healing molecules in each capsule.

Anti-inflammatory

Curcumin – a safer and superior alternative to NSAIDs

• Studies have demonstrated that curcumin switches off inflammation at a molecular level by acting on molecules like prostaglandins that trigger an inflammatory response.
• Curcumin achieves this by blocking cyclooxygenase-2 (COX-2), an enzyme that is crucial for the synthesis of prostaglandins.[6]
• This biochemical intervention also suppresses other molecules which mediate inflammation in the body like cytokines, interleukin-6, and histamine.[6]
• Curcumin also promotes the synthesis of Cortisol, a hormone that naturally reduces inflammation, and flushes out inflammation-causing toxins out of joints.[6]
• The use of curcumin has been demonstrated to be particularly effective against inflammation arising from osteoarthritis and rheumatoid arthritis, tendinitis, ulcerative colitis, and irritable bowel syndrome.[3]

CoQ10 reduces cardiac-related inflammation

• CoQ10 has shown promising results in reducing inflammation, especially in patients recovering from heart treatments.
• Post supplementation with CoQ10, patients showed lowered levels of interleukin-6 and C-reactive protein[7], which are markers for cardiac-related inflammation.
• Studies also indicate that CoQ10 supplementation can significantly reduce inflammation in individuals suffering from coronary artery disease.[7]

Antioxidant

The antioxidant potential of curcumin

• Research indicates that curcumin combats free-radical damage of cells associated with conditions like atherosclerosis and neurodegenerative disorders.[11]
• Curcumin’s role as antioxidant goes hand-in-hand with its anti-inflammatory action. As an antioxidant, curcumin aids in the prevention of tissue damage, and boosts immune function.

CoQ10 combats oxidative-damage to cells

• CoQ10 can easily donate electrons to other cells in the body and neutralize free radicals, thus protecting cellular components like lipids, DNA and protein against free-radical damage.[8]
• Further, CoQ10 can mobilize vitamin E – another antioxidant – that prevents cell death, maintains youthfulness of skin, and cuts down the risk of conditions like Alzheimer’s disease.
• The antioxidant mechanism of CoQ10 has also been demonstrated to be highly effective against heart disease[7], immune disorders[9], and periodontal disease.[10]

Heart protection

Curcumin’s role in cholesterol management

• The oxidation of cholesterol increases the risk of heart diseases by damaging blood vessels in the heart and causing plaque formation.
• Studies have indicated that curcumin can prevent the accumulation of oxidized cholesterol in the body, thereby lowering the risk of heart attacks and strokes.[14]
• Curcumin’s cardiac protection also extends to heart disease associated with atherosclerosis and diabetes.
• Studies have demonstrated the cholesterol-lowering function of curcumin. High LDL levels cause deposition and blockage in the walls of arteries. Curcumin signals proteins in the liver to actively flush out LDL out of the body- thus, lowering harmful LDL levels in the body.[14]
• In fact, CurQ10’s heart protection is not just recommended for heart patients and cholesterol drug lowering users, but for individuals from all walks of life to maintain heart health, manage cholesterol levels, and add years to their heart

CoQ10 – a natural sentinel for the heart

• CoQ10 is essential to all energy-dependent processes in the body, including heart contraction and other cardiac functions.
• The levels of CoQ10 can get rapidly depleted in heart patients, especially in heavy cholesterol drug lowering users.[12] CurQ10 ensures that CoQ10 levels in the body are adequate for the proper functioning of the heart. Consumption of CurQ10 protects cholesterol drug lowering users from excessive depletion, and helps in managing the risk of developing heart conditions.
• CoQ10 keeps cardiac conditions such as arteriosclerosis, cardiomyopathy, arrhythmia, and hypertension at bay.[13]
• As an antioxidant and anti-inflammatory, CoQ10 has also been shown to reduce markers associated with cardiac stress and myocardial infraction.[7]

Anti-ageing

Curcumin wards off signs of ageing

• Curcumin slows down signs of mental ageing, and lowers the risk of brain degeneration, cognitive decline, and neurodegenerative disorders.[11]
• Studies also indicate that curcumin reduces signs associated with physiological ageing such as arterial stiffness and oxidative stress.[15]
• Curcumin has also been shown to improve endothelial function[16], which is closely related to maintaining heart health and immune function.
• Further, curcumin boosts the production of collagen, a protein that maintains the elasticity and firmness of skin.[17]

CoQ10 can improve longevity of cells

• CoQ10 is an essential component of most cells in the body, as it helps the mitochondria in energy generation.[18]
• Mitochondria are the energy centers of cells, and studies have shown that mitochondrial function is closely related to ageing.
• Oxidative damage to mitochondria accelerates the ageing process, and this is effectively countered by the antioxidant function of CoQ10.[19]
• Supplementation with CoQ10 also reverses mitochondrial damage, which can potentially slow down the ageing process.
• CoQ10 is also shown to directly impact the expression of genes that control the ageing process, thus controlling the ageing process at a genetic level.[19]

Benefits

CurQ10 offers a variety of therapeutic and protective advantages to diverse individuals across age, gender, and activity levels. Along with bringing relief to individuals suffering from specific conditions like arthritis and cardiac disease, CurQ10 is recommended for use for all individuals on a regular basis to boost immune function, heart health and joint health. CurQ10 is also highly beneficial for active individuals like athletes for improving their performance, and lowering their risk of injury and inflammation.

Women

Women are more likely to suffer from joint pain and inflammation as a result of arthritis, osteoarthritis, and rheumatoid arthritis.[23] The risk of arthritis in women increases significantly post menopause.[24] Owing to curcumin’s potent anti-inflammatory function, CurQ10 can relieve joint pain in women arising from arthritis, osteoarthritis, and rheumatoid arthritis. CurQ10 may also protect women from inflammation specific to the menstrual cycle, like lower back pain.

Athletes

As CoQ10 is extensively involved in energy production, it is of particular interest to athletes and physically active individuals. CoQ10 is known to increase aerobic capacity and endurance, reduce oxidative stress, and improve muscle performance.[9] Regular consumption of CurQ10 may result in superior aerobic performance and faster muscle recovery athletes and active individuals.[25]

With the COX-2 blocking mechanism of curcumin, CurQ10 is a more efficacious and safer alternative to NSAIDs against inflammation.[26] Curcumin also boosts the healing and repair of joints, thereby reducing the risk of injury during intense physical activity. Curcumin supplementation has also been shown to reduce DOMS (delayed onset muscle soreness) in athletes.[27] CurQ10 can help athletes combat the repetitive stress to their muscles and other connective tissue, and fortifies bones and joints against potential damage due to intensive training.

Elderly

CoQ10 levels in the body deplete with age, particularly past the age of 40. Rapid depletion of can lead to cellular damage and death, and the slowing down of energy production in the body. CurQ10 helps maintain healthy CoQ10 levels in elderly individuals, thus helping to restore energy levels, counter cellular damage, and maintaining immune function.[29]

Arthritis, osteoarthritis, and loss of bone mineral density resulting from ageing are a major cause of inflammation in the elderly.[30] CurQ10 relieves inflammation resulting from these conditions and flushes out inflammation-causing toxins from joints. Supplementation with CurQ10 can help improve mobility issues in the elderly and slow down the effects of arthritis.

Both CoQ10 and curcumin have also shown promise in delaying the onset of neurodegenerative disorders like Dementia and Parkinson’s disease, and cognitive decline.[11]

In CurQ10, elderly individuals have an all-encompassing, safe, and 100% natural supplement that brings relief from multiple conditions associated with advanced age.

Vegans

CoQ10 is found in limited food sources, which are largely non-vegetarian like pork and beef. Moreover, dietary sources of CoQ10 would have to be consumed in large quantities (for e.g. 206 cups of broccoli or 17 pounds of peanuts) to meet the recommended daily requirement.[31] Vegan sources of CoQ10 are even more limited, thus making supplementation essential for vegans to maintain healthy levels of CoQ10.

CurQ10 is a 100% vegan/vegetarian supplement that contains no animal-ingredients, and is a safe and ethical way to meet one’s recommended dietary intake of CoQ10. Further, the formulation of CurQ10 has been optimized with the addition of 10mg of Piperine per serving to ensure high bio-availability of CoQ10.[32]

FAQ

What is CurQ10?

CurQ10 is 100% natural supplement formulated from 306mg fermented Coenzyme Q10, 10mg Piperine, and 100mg standardized phytochemical extracts of Curcumin. CurQ10 offers wide-ranging anti-inflammatory, antioxidant, heart protection, and anti-ageing.

Who should use CurQ10?

CurQ10 is beneficial for wide-spectrum of people because of its multifarious applications across conditions. CurQ10 is recommended for those suffering from joint pain and inflammation resulting from arthritis, osteoarthritis, and rheumatoid arthritis. It also lends heart-protection to cardiac patients, particularly statin users. Additionally, CurQ10 offers diverse benefits to the elderly, women, and athletes for overall health. CurQ10 is recommended for all individuals above 18 years of age for maintaining healthy heart function, joint health, and immune health.

Is CurQ10 safe for long-term use?

Yes, CurQ10 is a 100% natural supplement with no side-effects that is safe for long term and short term use. If you are pregnant or breastfeeding, or if you suffer from a serious condition, we recommend that you consult your doctor before taking CurQ10.

Does CurQ10 have any drug interactions?

CurQ10 is completely safe for long-term use, and is generally well tolerated by most individuals. CurQ10 has no known drug interactions.

Is CurQ10 suitable for vegans?

CurQ10 is 100% vegan, and registered vegan by the Vegan Society, UK. CurQ10 is not just suitable for vegans, but recommended for them. Dietary food sources of CoQ10, which are already limited, are even scarcer for vegans. CurQ10 offers 306mg of bio-identical and bioavailable CoQ10 to meet the recommended dietary requirements of vegans and vegetarians.

Is CurQ10 useful for athletes?

Athletes stand to benefit a great deal from CurQ10 supplementation. The combined mechanism of curcumin and CoQ10 can help athletes enhance their aerobic performance, lower their recovery times, and protect their joints against oxidative stress and inflammation.

How should CurQ10 be taken?

CurQ10 should be taken once a day with a meal, or as directed by your physician.

References

1. Venugopal P. Menon and Adluri Ram Sudheer , The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Advances in experimental medicine and biology volume 595, 2007, pp 105-125.

2. John. C. Martin, LE Magazine, September 2001.

3. Venugopal P. Menon and Adluri Ram Sudheer, Antioxidant and anti-inflammatory properties of curcumin, The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Advances In Experimental Medicine And Biology, Volume 595, 2007, pp 105-125.

4. Dr. Chad Larsen, Coenzyme Q10: multiple benefits in one ingredient. OCL 2011; Vol. 18(2), pg. 76-82.

5. Kumar et al, Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome, Pharmacology & Therapeutics, 124 (2009), 259-268, Elsevier.

6. M. Akram et al., Curcuma longa and Curcumin: A Review Article, Rom.J. Biol. – Plant Biol., Volume 55, no. 2, p. 65–70, Bucharest, 2010.

7. Lee et al., Effects of coenzyme Q10 supplementation on inflammatory markers (high-sensitivity C-reactive protein, interleukin-6, and homocysteine) in patients with coronary artery disease, Nutrition. 2012 Jul;28(7-8):767-72. doi: 10.1016/j.nut.2011.11.008. Epub 2012 Feb 17.

8. Nachiket S Dighe et al., CoQ10, A wonder enzyme, A review, Der Pharma Chemica, 2010, 2(1): 236-250.

9. Alan R. Gaby, MD, The Role of Coenzyme Q10 in Clinical Medicine: Part II, Alternate Medicine Review, Volume 1, Number 3, 1996.

10. Hans et al., Role of coenzyme Q10 as an antioxidant and bioenergizer in periodontal diseases, Indian J Pharmacol. 2010 Dec; 42(6): 334–337.

11. Cox et al., Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population, British Association for Psychopharmacology, October 2, 2014 0269881114552744.

12. Lee et al., Effects of coenzyme Q10 supplementation (300 mg/day) on antioxidation and anti-inflammation in coronary artery disease patients during statins therapy: a randomized, placebo-controlled trial, Nutrition Journal, 2013, 12:142.

13. Adarsh Kumar, HarpreetKaur, Pushpa Devi, Varun Mohan, Role of Coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome, Pharmacology & Therapeutics, 124 (2009), 259-268, Elsevier.

14. Alwi et al., The effect of curcumin on lipid level in patients with acute coronary syndrome, PubMed, 2008. http://www.ncbi.nlm.nih.gov/pubmed/19151449

15. Sikora et al., The promise of slow down ageing may come from curcumin, Curr Pharm Des. 2010;16(7):884-92.

16. Curcumin shows anti-ageing potential. http://www.emaxhealth.com/1275/curcumin-shows-antiaging-potential-new-studies

17. Pancharatnam et al., Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species, Molecular and Cellular Biochemistry, October 2006, Volume 290, Issue 1-2, pp 87-96.

18. Alan R. Gaby, MD, The Role of Coenzyme Q10 in Clinical Medicine: Part I, Alternate Medicine Review, Volume 1, Number 1, 1996. Trefil, 1992, p.93 in Jerry Bergman, ATP: The Perfect Energy Currency for the Cell, CRSQ Volume 36(1), June, 1999.

19. Lina Buchanan, CoQ10: The Longevity Factor http://www.lef.org/Magazine/2013/1/CoQ10-The-Longevity-Factor/Page-01?checked=1

23. Callahan LF. Et al., Arthritis and Women’s Health: prevalence, impact and prevention, Am J Prev Med. 1996 Sep-Oct;12(5): 401-9 in Verbrugge LM., Women, men, and osteoarthritis, Arthritis Care Res. 1995 Dec;8(4):212-20.

24. Aging Changes in the Bones – Muscles – Joints, Medline Plus, US National Library of Medicine, NIH.

25. MichihiroKon et al., Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10, British Journal of Nutrition, (2008), 100, 903-909.

26. Reji K, ‘Clinical evaluation of a formulation containing Curuma longa and Boswellia serrata extracts in the management of knee Osteoarthritis,’ Molecular Medicine Reports, November 2013, Volume 8(5), November 2013.

27. Anthony D Wolf & Bruce Pfleger,Burden of Major Musculoskeletal Conditions, Bulletin of the World Health Organization, pg 646, 2003, 81 (9).

28. Eugene Z, Ellen K, Natural Support for Autoimmune and Inflammatory Disease, Journal of Restorative Medicine,2013.

29. Emile G. Bliznakov, M D, Coenzyme Q10, Lipid Lowering drugs (Statins) and Cholesterol: A present day Pandora’s Box , The Journal of American Neutraceutical Association, Vol. 5(3), 2002, pg. 32-38.

30. Hughes SL., Dunlop D., ‘The prevalence and impact of arthritis in older persons’, Arthritis Care Res. 1995 Dec; 8(4):257-64.

31. Dr. Stephen Sinatra, ‘Take a CoQ10 supplement for Heart Health’, www.drsinatra.com.

32. Umesh K Patiletal., Role of Piperine as a Bioavailability Enhancer, International Journal of Recent Advances in Pharmaceutical Research, October 2011, 4: 16-23.