3.6:1 or 40:1 – Ratio or Concentration?
Administration of exogenous DCI may be a means of bypassing defective epimerase activity and achieving the downstream metabolic effects of insulin in DCI‑deficient tissues. Epimerase activity is unidirectional, and DCI administration alone will not be able to mimic the effects of MI. Therefore, it is rational to provide a combination of both to ensure optimal insulin sensitivity[v].
While MI is necessary for metabolic management, DCI is equally important for menstrual, ovulatory, and cutaneous hyperandrogenic resolution. Therefore, the ratio may be less important than the absolute concentrations of both inositols. It is clear, therefore, that a high concentration of DCI is necessary to circumvent epimerase deficiency and ensure adequate levels in the ovary[v].
- A study was performed to evaluate the efficacy of MI and DCI ratios for increasing the fertility rate. The primary outcome was the pregnancy rate, and the secondary outcomes were oocyte maturation, embryo quality, testosterone levels and insulin sensitivity[vi].
- This was a multicenter controlled, randomized, double-blind parallel group study with two MYO-DCI formulations for 12 weeks. The study group (SG) was administered 550mg of MYO + 150mg of DCI twice daily; the control group (CG) was administered 550mg of MYO + 13.8mg of DCI twice daily[vi].
- The participants comprised 60 women with PCOS undergoing ICSI. At baseline, no differences were found between the two groups regarding age, BMI, HOMA-IR or testosterone levels6.
- The pregnancy and live birth rates were significantly higher in the SG than in the CG (65.5 vs. 25.9 and 55.2 vs. 14.8, respectively)[vi]
- The combination of MYO-DCI at high doses of DCI improves the pregnancy rates and reduces the risk of OHSS in women with PCOS undergoing ICSI[vi].
- The primary findings of this study show that high doses of DCI combined with MYO increase the percentage of pregnancy rates in women with PCOS undergoing ICSI[vi].
MYO and DCI can improve the outcomes by diverse mechanisms: improving insulin sensibility, increasing ovulation or reducing oxidative stress of follicular fluid6. The main strength of this study is that the pregnancy rates are high with 150 mg of DCI twice daily and could involve DCI in early embryonic implantation and development6. Thus we can say that higher DCI helps maintain an environment to support implantation of embryo and increases the chances of pregnancy and live births.
Why Unived’s PCOS Fertility?
Unived’s PCOS Fertility product is formulated with Myo-Inositol and Caronositol® D-Chiro-Inositol and folate in it bioactive form. Caronositol® is a natural Plant-Based DCI from carob extract obtained by a patented process in a ratio of 3.6:1 MI:DCI which is way higher in concentration of DCI as compared to the physiological ratio of 40:1. DCI helps reduce hyperandrogenism and skin disorders in women suffering with PCOS. It helps PCOS affected women by regulating normal ovulation.
We created PCOS Fertility using the two inositols in this ratio because we had to believe in facts and that is; in PCOS,
- MI to DCI conversion is impaired
- DCI is deficient
- DCI deficiency increases insulin resistance
- This leads to DCI paradox in the ovaries i.e. more MI to DCI conversion and excessive release of androgens.
- 3.6:1 ratio has shown an increase in pregnancy rates and live birth rates.
Thus is just makes more sense to supplement with a higher amount of DCI in combination with MI if one with PCOS is aiming to conceive.
Although Unived’s PCOS Fertility does not guarantee pregnancy to you because pregnancy could be affected by a number of factors depending on both partners, but it will help reduce the factors related to PCOS that might be hindering conception.