Biotin is an important B-complex vitamin (vitamin B7). Its deficiency is very well recorded during pregnancy and associated with skin problems, brittle and weak hair & nails, problems in regulation of genes that are critical in the regulation of intermediary metabolism.
Unived’s Organic Whole Food Plant Based Biotin with Organic Vitamin C features our unique Organic BioC Blend, providing 5000mcg of Biotin 50% RDA of vitamin C. It also contains natural sodium which is essential for maximum absorption of the two nutrients.
Beneficial effects on hair, skin & nails is not the only function of biotin. It plays various roles in the human body, such as, it acts as a prosthetic group of carboxylase enzymes (basically activation of enzyme), pharmacological doses of biotin appear to affect carbohydrate metabolism. It also helps maintain triglyceride and VLDL levels and has a wide repertoire of effects on systemic processes such as development, immunity and metabolism. As serum biotin levels are low during pregnancy, there is increased requirement.
WHO SHOULD TAKE IT?
Biotin in general can be taken by anybody and everybody as it is a water soluble vitamin and cannot be produced or stored by the body. This increases chances of one being deficient in this B-complex vitamin & diminishes possibility of toxicity. Unived’s Organic Whole Food Plant Based Biotin also contains vitamin C which has various applications in life like collagen synthesis, protection of cells from free radicals, increasing iron absorption etc. Thus it is an ideal choice for people looking for just biotin to fight the varied problems of hair, skin, nails, metabolism, high TG and VLDL levels etc.
KEY PRODUCT HIGHLIGHTS:
- 5000mcg of natural biotin from organic sources with natural vitamin C meeting 50% of daily requirement.
- Packed with sodium that enhances utilization of these two vitamins.
- Made with natural ingredients and contains Organic Whole Foods
- No harmful chemicals
- Helps in activation of enzymes that are involved in various metabolic pathways necessary for daily functions
- Helps maintain healthy lipid profile
- Helps diminish problems associated with biotin deficiency by maintaining healthy serum biotin levels
- May prevent hair loss, brittle nails and some skin problems that may be because of low biotin levels
- Suitable for adult men, women, vegans
- 60 vegan capsules = 1 month supply
MODE OF ACTION
Normal skin contains high concentrations of vitamin C, with levels comparable to other body tissues. Ascorbate is a cofactor for the enzymes catalyzing the synthesis of collagen,. In addition to its role in collagen synthesis, vitamin C acts as a powerful antioxidant by neutralizing deleterious reactive oxygen species3,.
- Protein synthesis: The synthesis of collagen and noncollagen proteins was stimulated by ascorbate2.
- Wound healing: Vitamin C has an essential role in connective tissue healing10 that vitamin C increases proliferation and migration of dermal fibroblasts functions vital for effective wound healing1, 3
- Vitamin C uptake from the plasma and transport across the skin layers is mediated by specific sodium-dependent vitamin C transporters (SVCTs) that are present throughout the body1.
- Keratin synthesis: In vitro studies clearly show that vitamin C can play a role in the differentiation of keratinocytes1,3
- Photoprotection: it improved resistance to UVA, decreased MDA and TBA levels, increased GSH levels, decreased IL-1 and IL-6 levels1,3.
- Protects cells: it prevents lipid peroxidation in cultured keratinocytes following UV exposure and also protects the keratinocyte from apoptosis and increases cell survival1,3.
- Wrinkle formation: vitamin C status could protect against wrinkle formation1.
Biotin (vitamin B7):
Biotin is a water-soluble B vitamin that is an essential co-factor for four carboxylase enzymes, each of which catalyzes an essential step in intermediary metabolism. Because humans and other mammals cannot synthesize biotin, it must be derived from dietary sources. Conditions that may benefit from biotin supplementation include dyslipidemia, brittle nails, diabetes, dermatitis, and candidiasis. Thus biotin is involved in fatty acid synthesis, amino acid catabolism, gluconeogenesis, and mitochondrial function in hair root cells6
- Reduces the incidences of brittle nails called Onychoschizia5.
- Biotin deficiency can cause alopecia and scaly, erythematous dermatitis distributed around body orifices5.
- Poor biotin status adversely affects plasma lipid levels. Biotin resulted in significant decreases in triglycerides and very low-density lipoproteins (VLDL) in both diabetic and non-diabetic subjects compared to placebo5.
- Acquired biotin deficiency and the disorders of biotin metabolism lead to a deficiency of the four biotin-dependent carboxylase enzymes (ie., multiple carboxylase deficiency)
- Deficiency causes problems: Biotin deficiency was reported in patients complaining of hair loss. Biotin was an effective supplementation for hair regrowth6.
- Signs of biotin deficiency include hair loss, skin rashes, and brittle nails
- Keratin synthesis: Biotin’s function in protein synthesis and more specifically, in keratin production, explains its contribution to healthy nail and hair growth7,6.
- Hair loss & brittle nails: 18 reported cases of biotin use for hair and nail changes. In all cases, patients had an underlying pathology for poor hair or nail growth. All cases showed evidence of clinical improvement after receiving biotin,7.
- Finally, 3 cases of brittle nail syndrome treated with biotin were found in the literature and each case showed improvement of nail strength7.
- Biotin supplementation is also effective on alopecia, uncombable hair syndrome & brittle nail syndrome7.
- Because it contains Sulphur it influences the state of skin integument lowering sebum secretion and activates hair growth.
- Sodium dependent multivitamin transporter (SMVT) is an electrogenic, highly sodium dependent carrier mediated system responsible for absorption of vitamins. It is an important transmembrane protein responsible for translocation of vitamins.
- The Na+/multivitamin transporter (SMVT) is a member of the Solute Sodium Symporter (SSS) family that catalyzes the Na+-dependent uptake of the water-soluble vitamins pantothenic acid (vitamin B5) and biotin (vitamin H), alpha-lipoic acid and is therefore, essential for normal human health and development.
- Humans cannot synthesize Vitamin C. Its intestinal transport occurs via a carrier-mediated Na+ dependent mechanism localized at the brush border membrane.
 Juliet M. Pullar, et. al., “The Roles of Vitamin C in Skin Health”, Nutrients 2017, 9, 866
Saood Murad, et. al., “Collagen Synthesis in Cultured Human Skin Fibroblasts: Effect of Ascorbic Acid and Its Analogs”, The Journal Of investigative Dermatology, 81:158-162, 1983
 Maria Valeria Catani, et. al., “Biological Role of Vitamin C in Keratinocytes”, Nutrition Reviews®, Vol. 63, No. 3. International Life Sciences Institute2005
 Nicholas N. DePhillipo, “Efficacy of Vitamin C Supplementation on Collagen Synthesis and Oxidative Stress After Musculoskeletal Injuries A Systematic Review”, The Orthopaedic Journal of Sports Medicine 2018
 “Biotin monograph”, Alternative Medicine Review Volume 12, Number 1 2007
 Anna-Marie Hosking, et. al., “Complementary and Alternative Treatments for Alopecia: A Comprehensive Review”, 2018 S. Karger AG, Basel
 Hind M. Almohanna, et. al., “The Role of Vitamins and Minerals in Hair Loss: A Review”, Dermatol Ther (Heidelb) (2019) 9:51–70
 Deepa P. Patel, et. al., “A Review of the Use of Biotin for Hair Loss”, Skin Appendage Disord 2017;3:166–169
 Zuzanna Sabina Goluch-Koniuszy, “Nutrition of women with hair loss problem during the period of menopause”, Menopause Review/Przegląd Menopauzalny 15(1) 2016
“Niacin monograph”, Alternative Medicine Review Volume 7, Number 6 2002
William B. Grant , et. al., “Benefits and Requirements of Vitamin D for Optimal Health: A Review”, Alternative Medicine Review Volume 10, Number 2, 2005
Pawel R. Kiela et. al., “Physiology of Intestinal Absorption and Secretion”, Best Pract Res Clin Gastroenterol. 2016 April ; 30(2): 145–159.