Unived Nootro-Peak

Description

Nootro-Peak has been formulated with ingredients that play an active role in mental focus, alertness, memory, reaction time, & relaxation. Caffeine and L-Theanine synergize to optimize athletic performance and are proven to improve cognition to a greater extent when taken together in the proven 1:2 ratio. Acetyl-L-Carnitine enhances blood flow and supports muscle recovery.

5-HTP extracted from Griffonia simplicifolia is a precursor to the neurotransmitter serotonin and helps enhance the regulation of mood and behavior.

Vitamin B complex contains 7 essential B- vitamins, all of which are involved in improving cognitive function, increasing focus and extending short & long-term alertness. Unlike traditional caffeine capsules or energy drinks- you will not experience a crash with this product.

Benefits of Natural Nootropic Supplements

• Steady and focused energy
• Focus & clarity of mind
• Improved reaction time
• Positive mood and overall relaxation
• Reduced stress
• No crash
• No jitters

Caffeine & L-Theanine Synergy in Nootropic Supplements

Caffeine + L-Theanine have synergistic effects on cognition – meaning that together they produce cognitive benefits not seen when either is used alone. The specific ratio of 1:2 of caffeine to L-Theanine in Nootro-Peak nootropic supplements matches the dosage widely shown in clinical trials to produce optimal performance gains. In clinical trials the 1:2 ratio of Caffeine to L-Theanine has been proven to:

• Increase Sustained Attention by 13.94%: sustained attention is calculated by testing a variance of cognitive variables including, digit vigilance, digit accuracy and digit false alarms(12)
• Increase Semantic Memory by 3.34%: semantic memory is calculated by testing cognitive variables such as word recognition, word recognition reaction time and delayed word recall (12)
• Increase Simple Reaction time by 9.27%: controlled clinical testings have shown significant increases in simple reaction time (tested by capturing the time taken to react to a screen by pressing a button) (12)
• Increase Self Reported Alertness by 19.49%: throughout multiple studies conducted, patients reported increased alertness 1 hour after after ingestion of Caffeine + L-Theanine (12)

Ingredients

Key Ingredients of Unived’s Nootro-Peak Nootropic Supplements are as follow –

L-THEANINE

L-Theanine is an amino acid analog of glutamate and glutamine found in green tea from Camellia sinensis with neuroprotective effects. L-Theanine has anxiolytic activity and is clinically proven to have favorable effects on reducing stress & anxiety, as well as reduce blood pressure and cerebral vascular restriction caused by caffeine intake.

Mechanisms:

• Increases alpha brain waves – promotes attention and relaxation without sedation
• Synergistic with caffeine in promoting concentration, motivation and memory
• Can modulate the release of Dopamine, improving mood
• Antioxidant effects and protects neurons from damage and hypoxia
• May upregulate the production of proteins associated with neuronal growth
• Works by reducing your stress levels so you can think clearer and stay calmer throughout the day

CAFFEINE

Caffeine is a methylxanthine found in tea. Caffeine is clinically proven as a brain stimulant that increases alertness, wakefulness, attention, working memory, and motor activity.

Mechanisms:

• It increases alertness and is brain stimulator
• It helps to increase performance and reduces time to exertion by providing energy
• Increases motor activity through inhibition of acetyl cholinesterase
• Increases cortical activation in the brain
• Increases information processing rate and concentration
• Increases cerebral metabolism

Acetyl-L-Carnitine

Scientific data indicates that the athletic population can benefit from L-carnitine intake as it attenuates the side effects of high-intensity training by reducing the magnitude of exercise-induced hypoxia and muscle injury.

Mechanisms:

• L-carnitine on reducing exercise-induced hypoxia, subsequent muscle damage, and delayed onset muscle soreness (DOMS) was substantiated by certain studies.
• In a cross-over study, the supplementation with L-carnitine alleviated pain, tenderness and release of creatine kinase-a marker of muscle injury-indicating that the nutrient was effective in reducing tissue disruption and subsequent leakage of cytosolic proteins, which are proteins involved in many functions including signal transduction.
• One of the mechanisms of L-carnitine while supplementation during exercise recovery is its effect on mitigating oxidative stress during exercise.
• Supplementation with L-carnitine has been shown to increase physical performance and muscle mass and function.
• When serum and muscle L-carnitine increases on supplementation, it is suggested to enhance blood flow and oxygen supply to the muscle tissue via improved endothelial function thereby reducing hypoxia-induced cellular and biochemical disruptions.

5-HTP

Lowered cortisol levels and lowered serotonin levels are shown to pose a higher risk of anxiety and depression. 5-hydroxytryptophan is an amino acid which a precursor to serotonin.

Mechanisms:

• Supplementation with 5-HTP helps replenish the levels of the neurotransmitter serotonin- which is a hormone involved in regulating emotion, mood, sleep, and appetite

Vitamin B1 (Thiamin)

• It is required for the synthesis of fatty acids, steroids, nucleic acids and aromatic amino acids, which are precursors to a range of neurotransmitters, including acetylcholine, glutamate and gamma-aminobutyric acid.
• Lower dietary intake of vitamin B1 has a negative impact on memory and is associated with cognitive impairment, severe amnesia and loss of recent and working memory.
• Vitamin B1 supplementation could be effective in preventing cognitive impairment before a cognitive dysfunction occurs.

Vitamin B2: Riboflavin

• Anemia, a condition related to fatigue, is associated with low riboflavin status. Hence, riboflavin deficiency enhances the risk of associated fatigue symptoms.
• A study found that improved levels of riboflavin have been found to increase circulating hemoglobin levels and improve the condition of anemia.

Vitamin B3: Niacin

• Niacin, vitamin B3 is of relevance in cognitive health and has roles in cerebral functioning. It is involved in the control of intracellular calcium release which is responsible for generating action potential in neurons.
• Inadequate niacin intake can lead to symptoms like weakness, loss of appetite, fatigue and apathy.
• Deficiency has been shown to lead to severe neurological symptoms, including depression and loss of memory.
• Niacin receptors are affected in several brain areas in people with Parkinson’s disease.
• Positive associations have been found between niacin (vitamin B3) status and the risk of Alzheimer’s disease and cognitive decline.
• Niacin supplementation was found to attenuate the disturbed sleep cycle associated with Parkinson’s disease.

Vitamin B5: Pantothenic acid

• It is required for the synthesis and release of neurotransmitters like acetylcholine in the synapse, hence, making it essential for the transduction of information in the brain.
• Similar to other B-vitamins, vitamin B5 is essential for a healthy sleep cycle and prevents symptoms like headache, fatigue and insomnia.
• In a particular study, a 2-week supplementation with pantothenic acid resulted in better performance for trained distance runners with better use of oxygen and less lactic acid accumulation.

Vitamin B12: Cobalamin

Methylcobalamin is a methylated and active form of Vitamin B12 (cobalamin) with strong neuroprotective and anti-aging effects. Methylcobalamin’s effects include improved memory and executive function, as well as enhanced focus.

Vitamin B12 is essential for generating new red blood cells, maintaining neurologic function, and DNA synthesis.[1]

Mechanisms:

• Acts as a cofactor for a number of enzymes and provides functional support for neurons
• Improves neuronal regenerative capacity and reduces neurotoxicity
• Can decrease neuropathy and neuropathic pain
• Removes excessive homocysteine in the brain – main cause of vascular degeneration
• Upregulates S-adenosylmethionine production – antidepressant effect
• Improves memory, concentration, executive function, and motor control
• Prevents age-associated cognitive decline

References for Nootropic Supplements

1. Deijen, J. B., van der Beek, E. J., Orlebeke, J. F., & van den Berg, H. (1992). Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl), 109(4), 489-496.

2. Bryan, J., Calvaresi, E., & Hughes, D. (2002). Short-term folate, vitamin B-12 or vitamin B-6 supplementation slightly affects memory performance but not mood in women of various ages. J Nutr, 132(6), 1345-1356.

3.Schneider, Z., & Stroinski, A. (1987). Comprehensive B12: chemistry, biochemistry, nutrition, ecology, medicine: Walter de Gruyter.

4. Dodd, F. L., Kennedy, D. O., Riby, L. M., & Haskell-Ramsay, C. F. (2015a). A double-blind, placebo-controlled study evaluating the effects of caffeine and L-theanine both alone and in combination on cerebral blood flow, cognition and mood. Psychopharmacology (Berl), 232(14), 2563-2576. doi:10.1007/s00213-015-3895-015.

5. Rogers, P. J., Smith, J. E., Heatherley, S. V., & Pleydell-Pearce, C. W. (2008). Time for tea: mood, blood pressure and cognitive performance effects of caffeine and theanine administered alone and together. Psychopharmacology (Berl), 195(4), 569-577. doi:10.1007/s00213-007-0938-116.

6. Foxe, J. J., Morie, K. P., Laud, P. J., Rowson, M. J., de Bruin, E. A., & Kelly, S. P. (2012). Assessing the effects of caffeine and theanine on the maintenance of vigilance during a sustained attention task. Neuropharmacology, 62(7), 2320-2327. doi:10.1016/j.neuropharm.2012.01.02017.

7. Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci, 13(6), 283-290. doi:10.1179/147683010×1261146076484018.

8. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol, 77(2), 113-122. doi:10.1016/j.biopsycho.2007.09.00819.

9. Kahathuduwa, C. N., Dassanayake, T. L., Amarakoon, A. M., & Weerasinghe, V. S. (2016). Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. doi:10.1080/1028415x.2016.114484520.

10. Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci, 11(4), 193-198. doi:10.1179/147683008×30151321.

11. Einother, S. J., Martens, V. E., Rycroft, J. A., & De Bruin, E. A. (2010). L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite, 54(2), 406-409. doi:10.1016/j.appet.2010.01.003

12. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., & Scholey, A. B. (2008). The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol, 77(2), 113-122. doi:10.1016/j.biopsycho.2007.09.008

13.Fielding R, Riede L, Lugo JP, Bellamine A. l-Carnitine Supplementation in Recovery after Exercise. Nutrients. 2018 Mar 13;10(3):349. doi: 10.3390/nu10030349. Erratum in: Nutrients. 2018 Apr 26;10(5): PMID: 29534031; PMCID: PMC5872767.

Tardy, A. L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020). Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients, 12(1), 228. https://doi.org/10.3390/nu12010228