The immune system undergoes many changes over the life course. Developing and maturing during childhood, potentially achieving peak function in early adulthood, and gradually declining in older age. Distinct immune features are present during each life stage, and speciﬁc factors differentially affect immune function, with a resulting difference in the type, prevalence and severity of infections with age. A common factor throughout life is the need for an adequate supply of micronutrients, which play key roles in supporting immune function.
Unived’s Immunity Builder is made with necessary and adequate micronutrients like Vitamin A, Vitamin E, Vitamin C, Vitamin D and mineral like Zinc that have scientific results of being effective in improving the functions of immune system. Unived’s Immunity Builder provides vitamins that are in their bioactive forms; it also provides zinc in its most bioavailable form.
WHO SHOULD USE
Vitamins should be taken routinely along with diet and are required in proper trace amounts so that all the barriers of the immune system such as skin, cell-mediated and humoral immune response etc. could be sustained. Thus, Unived’s Immunity Builder is recommended for all healthy adults, elderly individuals and people with compromised immune systems to assure one’s protection from various illnesses. It is safe and suitable for vegetarians and vegans and free from any impurities, fillers or other excipients.
IS IT NECESSARY?
Your immune system is a process of checks and balances that help fight and protect the body from disease and illness. It is possible to naturally boost your immune system – and easier than you probably think. If you are lacking some of these vitamins, a supplement could help support your immune system. Therefore to strengthen your immune system it is necessary that you take a supplement like Unived’s Immunity Builder to ensure that your body has a good reserve of these immunity builder micronutrients at all times.
|Vitamin A (as Beta-Carotene)||4000 mcg||83%|
|Vitamin C (as Ascorbic Acid)||250mg||625%|
|Vitamin D3 (as Cholecalciferol)||1000 I.U.||250%|
|Vitamin E (as d-Alpha-Tocopherol)||10mg||100%|
|Zinc(as Zinc citrate)||12mg||100%|
MODE OF ACTION
The immune system, which is integrated into all physiological systems, protects the body against infections and other external and internal insults by utilizing three distinct layers, depending on the nature of the threat:
- Physical (e.g., skin, epithelial lining of the gastrointestinal and respiratory tracts) and biochemical barriers (e.g., secretions, mucus, and gastric acid),
- Numerous different immune cells (e.g., granulocytes, CD4 or CD8 Tand B cells), and
- Antibodies (i.e., immunoglobulins).
The first line of defense is innate immunity, which combines physical and biochemical barriers with a non-specific leukocyte-mediated cellular response to defend against pathogens. If the pathogen manages to avoid these innate defenses, a more complex, adaptive, antigen-specific response is triggered, mediated by T and B lymphocytes, which produces antibodies to target and destroy the pathogen[i]. The most important cell in our body which protect from diseases is white blood cells (WBC) or Leukocytes which destroy disease causing substances.
[i] Silvia Maggini, et al, “Immune Function and Micronutrient Requirements Change over the Life Course”, Nutrients 2018, 10, 1531; doi:10.3390/nu10101531
Vitamin A: it is a micronutrient that is crucial for maintaining vision, promoting growth and development, and protecting epithelium and mucus integrity in the body
- VitA is known as an anti-inflammation vitamin because of its critical role in enhancing immune function1.
- VitA is involved in the development of the immune system and plays regulatory roles in cellular immune responses and humoral immune processes1.
- Helps maintain structural and functional integrity of mucosal cells in innate barriers (e.g., skin, respiratory tract, etc.)1
- Important for normal functioning of innate immune cells (e.g., NK cells, macrophages, neutrophils)1
- Necessary for proper functioning of T and B lymphocytes and thus for generation of antibody responses to antigen1.
- Involved in development and differentiation of Th1 and Th2 cells and supports Th2 anti-inflammatory response1.
Vitamin D: Vitamin D can modulate the innate and adaptive immune responses. Vitamin D functions as a modulator of up to 1000 genes involved in cellular growth, immune function and protein synthesis[i].
- Vitamin D receptor are expressed in innate immune cells (e.g., monocytes, macrophages, dendritic cells)1.
- Increases the differentiation of monocytes to macrophages1.
- Stimulates immune cell proliferation and cytokine production and helps protect against infection caused by pathogens1.
- 1,25-dihydroxyvitamin D3, the active form of vitamin D, regulates the antimicrobial proteins cathelicidin and defensin, which can directly kill pathogens, especially bacteria1.
- Deficiency of vitamin D is common among patients with inflammatory and autoimmune disorders and those with prolonged critical illness[ii].
- Vitamin D upregulates gene expression of broad spectrum antimicrobial peptides (AMP) – which are important regulators in innate immunity and also downregulates expression of inflammatory cytokines such as tumor neurosis factor-alpha (TNF-alpha) and interleukin-62.
Vitamin E: Vitamin E, a potent lipid-soluble antioxidant, found in higher concentration in immune cells compared to other cells in blood, is one of the most effective nutrients known to modulate immune function[iii]
- Protects the integrity of cell membranes from damage caused by free radicals1
- Enhances IL-2 production and NK cell cytotoxic activity1
- Enhances T cell-mediated functions and lymphocyte proliferation1
- Optimizes and enhances Th1 and suppresses Th2 response1
- Vitamin E modulates T cell function through directly impacting T cell membrane integrity, signal transduction, and cell division, and also indirectly by affecting inflammatory mediators generated from other immune cells4
- Appears particularly effective in improving age-associated deteriorations of immune and inflammatory responses4.
- Vitamin E inhibits PGE2 production by inhibiting enzymatic activity of cyclooxygenase 2 (COX-2) also reduces production of other inflammatory markers including tumor-necrosis factor (TNF-α) and IL-6, particularly in response to pathogens4.
Vitamin C: Vitamin C deficiency results in impaired immunity and higher susceptibility to infections
- It contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system1.
- Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity, thereby potentially protecting against oxidative stress1.
- The role of vitamin C has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene regulating effects1.
- Effective antioxidant that protects against ROS and RNS produced when pathogens are killed by immune cells1
- Regenerates other important antioxidants such as glutathione and vitamin E to their active state1.
- Promotes collagen synthesis, thereby supporting the integrity of epithelial barriers
- Stimulates production, function and movement of leukocytes (e.g., neutrophils, lymphocytes, phagocytes)1.
- Has a role in antimicrobial and NK cell activities and chemotaxis1.
- Involved in apoptosis and clearance of spent neutrophils from sites of infection by macrophages1.
- Can increase serum levels of antibodies, has roles in lymphocyte differentiation and proliferation1.
Zinc: Zinc is an essential mineral for the proper function of the immune, endocrine, and other systems. Zinc works to support the body’s natural defense system which aids and improves immune system function.
- Antioxidant effects protect against ROS and RNS1.
- Helps modulate cytokine release and induces proliferation of CD8+T cells1.
- Helps maintain skin and mucosal membrane integrity1.
- Central role in cellular growth and differentiation of immune cells that have a rapid differentiation and turnover1.
- Essential for intracellular binding of tyrosine kinase to T cell receptors, required for T lymphocyte development and activation1.
- Supports Th1 response1.
- Zinc is essential element for normal functioning of cells such as neutrophils and natural killer cells[iv].
- Adequate amounts of zinc can speed up the healing process and reduce the risk of falling ill, as it has the ability to exert an antiviral effect.
[i]D. Enette Larson-Meyer and Kentz S. Willis ‘Vitamin D and Athletes’, the American College of Sports Medicine2010
[ii]Alex Vasquez, et. al., ‘The clinical importance of vitamin d (cholecalciferol): a paradigm shift with Implications for all healthcare providers’, Alternative therapies, sept/oct 2004, vol. 10, no. 5
[iii] Erin Diane Lewis, et., al., “Regulatory Role of Vitamin E in the Immune System and Inflammation”,
[iv] Sabina Khanam, “Impact of Zinc on Immune Response”. Immunol Curr Res 2: 103 Volume 2 Issue 1, 1000104 (2018).