Unived’s CURCU-FREE™ (Curcumin Capsules) translates to ‘curcumin-free’, conveying exactly what this product does, which is delivering the highest amount of ‘free curcuminoids’ into the blood-stream plasma & organ tissue, more than any other curcumin extract on the market.
The curcumin we use for our curcumin capsules (CurQfen®) is a GREEN non-nano formulation, manufactured via a water based process with no synthetic emulsifiers – based on a green delivery technique (FenuMATTM).
CurQfen® is a 100% natural formulation of curcumin for enhanced absorption and systemic bioavailability upon oral administration. It is a patented ingredient developed using an in-house GREEN technology – FenuMATTM. CurQfen® is a unique combination of turmeric extract and debitterized fenugreek powder rich in soluble dietary fibre, formulated by a water-based process.
The functionalities of fenugreek soluble fibre/protein composite, such as high swelling index in water, gel-like character and gummy nature, helped to establish a strong binding of colloidal curcumin in the fiber network, providing a micro-encapsulation effect even when present in various food/beverage matrices, which provided protection against rapid metabolism during gastrointestinal transit.
Uniqueness of CurQfen® lies in its ‘free’ curcuminoids delivery, blood-brain-barrier permeability, longer half-life elimination and significant bioavailability at a low dosage. Curcuminoids in the free unconjugated form possess better antioxidant, anti-inflammatory, anti-proliferative, neuroprotective, anti-amyloidic and neurogenesis potential. The strong scientific background gives CurQfen® an upper hand over other competitor products.
CurQfen® is better than conventional curcumin extract because of its unique 100% natural formulation and better bioavailability of bioactive free curcuminoids over the glucuronide metabolites of curcumin, which are shown to have relatively weak antioxidant, anti-inflammatory and anti-proliferative activates. The conventional curcumin extract does not stay in the body in bioactive form, as it undergoes glucuronidation. Curcuminoids, namely curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) has revealed the properties such as poor water solubility, hydrophobicity, and instability under varying pH conditions of the gastrointestinal tract as the main reasons for its poor bioavailability. It stays in the body for a very short period and thus has a very poor absorption.
Various human studies have also demonstrated ‘free’ curcuminoids bioavailability (45.5-fold), pharmacokinetics, relative distribution of ‘free’ curcuminoids (>70%).
Working mechanism of CurQfen®
CurQfen® is a water dispersible formulation of curcumin with highly mucoadhesive and gastro-retentive and non-digestible, but fermentable prebiotic galacatomannans from fenugreek. Upon swelling in the gastrointestinal tract, colloidal and amorphous particles of curcumin leaches from the network and directly absorbed from the intestinal tract by crossing the membrane. High mucoadhesive character, water miscibility and small particle size provides better membrane permeability than the standard crystalline curcumin.
Clinically substantiated claims of CurQfen® are:
- Provides enhanced bioavailability and absorption of bioactive curcuminoids:
- CGM was found to deliver significantly high levels of plasma curcumin as compared to the standard unformulated curcumin when supplemented at 250 mg kg−1 b.wt in Wistar rats and 250 mg in humans. 
- Consumption of food/ beverages containing CGM was found to significantly enhance the plasma curcuminoid levels, as compared to standard curcumin with 95% purity, when administered as 1000 mg capsules. 
- After a single dose of 500 mg oral administration of CGM, the plasma levels of free curcuminoids were found to be significantly high at all the time points, when the absorption from standard curcumin was compared. 
- Enhanced absorption, bioavailability and tissue distribution of ‘free’ (unconjugated) curcuminoids for better bioactivity:
- Curcuminoids in the unconjugated form were shown to possess better antioxidant, anti-inflammatory, antiproliferative, neuroprotective, antiamyloidic, and antineuroinflammatory potential. 
- The results indicated a better absorption for Curcumin followed by DMC and BDMC with a relative enhancement of 45.5-folds in the total free curcuminoids plasma bioavailability for CGM as compared to the same dose of standard curcumin. 
- Provides longer duration and elimination half-life:
- The absorbed curcuminoids from CGM was found to stay in the blood for a longer duration. 
- Plasma concentration was continued at greater than 100 nM level for 12 h, leading to the conclusion that higher plasma curcumin concentrations for longer duration can be observed even with low doses of CGM. 
- Improved blood-brain-barrier permeability & brain bioavailability:
- ‘CGM’ has reported to exhibit improved BBB permeability and tissue distribution of all the three free curcuminoids (curcumin, DMC and BDMC). 
- Only the free form of curcumin was reported to have significant lipophilicity and ability to interact with the lipid head groups and thiols in membranes to induce BBB permeability. 
- Helps to reduce cardiovascular disease risk:
- CGM is a safe antioxidant-rich natural formulation of curcumin, possessing potent anti-inflammatory effect and might have implications for strategies that aim to prevent and attenuate cardiovascular diseases, especially atherosclerosis. 
- Helps to maintain healthy aortic stiffness in obese people and reduce aortic stiffness and brachial pulse pressure:
- A recent clinical study on young obese subjects has reported that CGM could reduce arterial stiffness among those who possess higher level of stiffness when treated with 500 mg dosage for 12 weeks. 
- A significant reduction in brachial PP, a surrogate marker for aortic stiffness, was observed in the curcumin group following12 weeks of curcumin treatment when compared to the placebo treatment. 
- Helps to enhance anti-inflammatory cytokines:
- CGM at a concentration of 12.5 μg/mL was found to be the potent dose to exhibit maximum anti-inflammatory effect (85%). 
- Supports optimum brain health & helps to reduce stress/anxiety/fatigue:
- Upon 30 days of supplementation, CGM showed a significant reduction (P< 0.01) of perceived stress as compared with the standard curcumin. 
- Of the overall study population was found to have moderate anxiety, which was significantly (P < 0.001) reduced upon CGM treatment. 
- Supports healthy antioxidant balance & detoxification:
- The extent of lipid peroxidation in the CGM group was found to have 8.95% reduction as compared with unformulated curcumin-treated group 2. 
- Helps to maintain healthy inflammatory levels by reducing inflammatory markers:
- Treatment with CGM significantly inhibited the translocation of p65 subunit and inhibited the action of NF-κB. 
- CGM administration significantly suppressed the iNOS expression which reduces the level of NO and peroxynitrite formation. 
- Hypolipidemic effect:
- Soluble dietary fiber of fenugreek (galactomannans) has already been established as a safe and versatile hydrocolloid possessing gelling, thickening, emulsifying, stabilizing, and encapsulating properties, with functional benefits such as hypolipidemic, hypoglycemic, appetite reducing, and gastroprotective effects. 
- A reduction in the total cholesterol and triglycerides was observed among the subjects when treated with CGM. 
- Helps to reduce alcohol mediated liver damage
- Hepatoprotective and supports healthy liver function markers
- Helps to maintain healthy glutathione levels
Combination of CurQfen® + Longperin™
Longperin™ is standardised to have 10% piperine content. Piperine isolated from black pepper at a particular dosage was shown to enhance the bioavailability. So, addition of Longperin™ at a suitable concentration may enhance the bioavailability of curcuminoids. Long pepper is also an important Ayurvedic herb with antioxidant, detoxification and anticancer potential as shown by published studies.
We recommend consuming one capsule daily along with your meal.
- Vijayasteltar B. Liju, et. al, ‘Enhanced bioavailability and safety of curcumagalactomannosides as a dietary ingredient’, The Royal Society of Chemistry 2014.
- Sangeeth Saji, et. al., ‘Curcumin–galactomannoside complex inhibits pathogenesis in Ox‑LDL‑challenged human peripheral blood mononuclear cells’, Springer International Publishing AG, part of Springer Nature 2018.
- Subash Pandaran Sudheeran, MSc, et. al., ‘Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress A Randomized, Double-Blind, Placebo-Controlled Pilot Study’, Wolters Kluwer Health, Inc. 2016.
- Dinesh Kumar, et. al., ‘Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study’, Elsevier Ltd. 2016.