Unived’s Curcumin Capsules CURCU-FREE translates to ‘curcumin-free’, conveying exactly what this product does, which is delivering the highest amount of ‘free curcuminoids’ into the blood-stream plasma & organ tissue, more than any other curcumin extract on the market. CURCU-FREE contains CURQFEN® which has proven health benefits like antiinflammation, lowering homocysteine levels and maintaining good heart health, protection against neuronal damage and learning and memory errors, helps reverse alcohol induced liver damage and helps maintain healthy lipid profile along with all the benefits of curcuminoids from conventional turmeric extract with an impact of 45.5 folds more than conventional turmeric extract. It is packed with Longperin™ providing 10% piperine which is also has antioxidant, detoxification and anticancer potential as shown by published studies.
Curcu-Free can be consumed by everybody for varied purposes, some would like to incorporate this product just as a natural antioxidant to enhance immunity, some would use it to reduce the effect of inflammation, and others might consider it to reverse the effect of alcohol consumption damage. Curcu-free is a versatile product which one can add to their daily regimen for various benefits without worrying about any side effects as the product is natural and vegan friendly.
WHAT IS INSIDE UNIVED’S CURCU-FREE?
CurQfen® is a 100% natural, GREEN non-nano formulation of curcumin for enhanced absorption and systemic bioavailability upon oral administration. It is a patented ingredient developed using an in-house GREEN technology – FenuMATTM. CurQfen® is a unique combination of turmeric extract and debitterized fenugreek powder rich in soluble dietary fibre, formulated by a water-based process.
Uniqueness of CurQfen® lies in its ‘free’ curcuminoids delivery, blood-brain-barrier permeability, longer half-life elimination and significant bioavailability at a low dosage. Curcuminoids in the free unconjugated form possess better antioxidant, anti-inflammatory, anti-proliferative, neuroprotective, anti- amyloidic and neurogenesis potential. The strong scientific background gives CurQfen® an upper hand over other competitor products.
WHY IS UNIVED’S CURCU-FREE BETTER?
CURCU-FREE contains CurQfen® which is better than conventional curcumin extract because of it’s;
- Unique 100% natural formulation
- Better bioavailability of bioactive free curcuminoids over the glucuronide metabolites of curcumin, which are shown to have relatively weak antioxidant, anti-inflammatory and anti-proliferative activates.
- It is bioactive: The conventional curcumin extract does not stay in the body in bioactive form, as it undergoes glucuronidation.
- Longer halflife: Curcuminoids, namely curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) has revealed the properties such as poor water solubility, hydrophobicity, and instability under varying pH conditions of the gastrointestinal tract as the main reasons for its poor bioavailability2. Thus conventional turmeric extract stays in the body for a very short period and thus has a very poor absorption.
- Various human studies have also demonstrated ‘free’ curcuminoids bioavailability (45.5-fold), pharmacokinetics, relative distribution of ‘free’ curcuminoids (>70%).
WORKING MECHANISM OF CURCU-FREE
CurQfen is a water dispersible formulation of curcumin with highly mucoadhesive and gastro retentive and non-digestible, but fermentable prebiotic galacatomannans from fenugreek.
The functionalities of fenugreek soluble fiber/protein composite, such as high swelling index in water, gel-like character and gummy nature, helped to establish a strong binding of colloidal curcumin in the fiber network, providing a microencapsulation effect which provided protection against rapid metabolism during gastrointestinal transit1.
Upon swelling in the gastrointestinal tract, colloidal and amorphous particles of curcumin leaches from the network and directly absorbed from the intestinal tract by crossing the membrane. High mucoadhesive character, water miscibility and small particle size provides better membrane permeability than the standard crystalline curcumin.
Clinically substantiated claims of CurQfen® are:
- Provides enhanced bioavailability and absorption and tissue distribution of bioactive curcuminoids:
- CGM was found to deliver significantly high levels of plasma curcumin as compared to the standard unformulated curcumin when supplemented at 250 mg kg−1 b.wt in Wistar rats and 250 mg in humans1.
- Consumption of food/ beverages containing CGM was found to significantly enhance the plasma curcuminoid levels, as compared to standard curcumin with 95% purity, when administered as 1000 mg capsules1.
- After a single dose of 500 mg oral administration of CGM, the plasma levels of free curcuminoids were found to be significantly high at all the time points, when the absorption from standard curcumin was compared. 
- Curcuminoids in the unconjugated form were shown to possess better antioxidant, anti-inflammatory, antiproliferative, neuroprotective, antiamyloidic, and antineuroinflammatory potential. 3
- The results indicated a better absorption for Curcumin followed by DMC and BDMC with a relative enhancement of 45.5-folds in the total free curcuminoids plasma bioavailability for CGM as compared to the same dose of standard curcumin2.
- Provides longer duration and elimination half-life:
- The absorbed curcuminoids from CGM was found to stay in the blood for a longer duration2.
- Plasma concentration was continued at greater than 100 nM level for 12 h, leading to the conclusion that higher plasma curcumin concentrations for longer duration can be observed even with low doses of CGM2.
- Improved blood-brain-barrier permeability & brain bioavailability:
- ‘CGM’ has reported to exhibit improved BBB permeability and tissue distribution of all the three free curcuminoids (curcumin, DMC and BDMC)2.
- Only the free form of curcumin was reported to have significant lipophilicity and ability to interact with the lipid head groups and thiols in membranes to induce BBB permeability2.
- Helps to reduce cardiovascular disease risk:
- CGM is a safe antioxidant-rich natural formulation of curcumin, possessing potent anti-inflammatory effect and might have implications for strategies that aim to prevent and attenuate cardiovascular diseases, especially atherosclerosis5.
- Helps to maintain healthy aortic stiffness in obese people and reduce aortic stiffness and brachial pulse pressure:
- A recent clinical study on young obese subjects has reported that CGM could reduce arterial stiffness among those who possess higher level of stiffness when treated with 500 mg dosage for 12 weeks5.
- Curcumin also improves indices of arterial health by enhancing endothelial function, reducing central BP, and decreasing augmentation index (AIx) scores (measure of arterial stiffness)4
- A significant reduction in brachial PP, a surrogate marker for aortic stiffness, was observed in the curcumin group following12 weeks of curcumin treatment when compared to the placebo treatment2.
- Reduces homocysteine levels:
- CGM improves homocysteine and HDL concentrations in young, obese men relative to a placebo group despite non-significant changes in endothelial function or BP.
- After 12 wk of intervention, plasma homocysteine concentrations were significantly reduced in the curcumin group compared with the placebo group4.
- Curcumin reduces homocysteine concentrations by 3.6 mg/ml, or a 29.5% decrease, in obese men4.
- Increases HDL levels:
- Curcumin has shown promise to favorably modulate CVD risk factors by lowering cholesterol and reducing oxidative stress and inflammation4.
- Serum HDL concentrations were elevated in the curcumin group at 12 wk compared with the placebo group4
- Helps to enhance anti-inflammatory cytokines
- CGM at a concentration of 12.5 μg/mL was found to be the potent dose to exhibit maximum anti-inflammatory effect (85%).
- Supports healthy antioxidant balance, Supports detoxification
- Reduced the amount of free radical formation5.
- The results indicate the protective role of CGM by effectively scavenging the free radicals (ROS) for reduced inflammatory conditions5.
- Reduces lipid peroxidation
- The extent of lipid peroxidation in the CGM group was found to have 8.95% reduction as compared with unformulated curcumin-treated group 23.
- Treatment with CGM along with ox-LDL showed a significant (p < 0.05) decrease in the level of TBARS compared to Group II5.
- Helps to maintain healthy inflammatory levels by reducing inflammatory markers:
- Treatment with CGM significantly inhibited the translocation of p65 subunit and inhibited the action of NF-κB5.
- CGM administration significantly suppressed the iNOS expression which reduces the level of NO and peroxynitrite formation5.
- Expressions of TNF-α, IL-6, VCAM-1 and iNOS in CGM treated group were reduced to normal, indicating anti-inflammatory effect of CGM5.
- treatment with CGM along with ox-LDL (Group III) resulted in the normalization of the level of LOX and PGE2 compared to Group II5
- Supports optimum brain health, Helps to reduce stress/anxiety/fatigue:
- Upon 30 days of supplementation, CGM showed a significant reduction (P< 0.01) of perceived stress as compared with the standard curcumin3.
- Of the overall study population was found to have moderate anxiety, which was significantly (P < 0.001) reduced upon CGM treatment3.
- Supports remyelination in multiple sclerosis:
- CurQfen® 400 mg/kg treated group show less demyelinated lesions when compared to curcumin and toxic group.
- CurQfen® offers greater protection and remyelination against Cuprizone induced models of MS6.
- Neuroprotective effects:
- CGM produced a significant effect in ameliorating the neuroinflammation and further changes associated with cognitive functions and neurotransmitter levels, indicating its potential in neurodegenerative disorders.
- Reduction in anxiety:
- On treatment with curcumin and CGM, there was a significant reduction in anxiety as compared to LPS-treated groups7.
- Reduces neuronal damage and learning & memory errors:
- The reference and memory errors were found to be significantly decreased on treatment with CGM with a significant reduction in the time taken to complete one session in RAM (Radial arm maze)7.
- CGM administration was found to increase the learning efficiency and memory of rats significantly when compared to the LPS-rats7.
- Neurotransmitter levels (serotonin dopamine)
- The levels of dopamine and serotonin showed a significant reduction in LPS treated Group II. On CGM treatment (Group III), these levels were found to be significantly increased (P < 0.001)7.
- Down regulation of NFkB expression
- CGM reduced inflammation caused due to activation and upregulation of NF-κB by down regulating it thus indicating its effectiveness to protect LPS-induced neuronal damage7.
- Hypolipidemic effect:
- Soluble dietary fiber of fenugreek (galactomannans) has already been established as a safe and versatile hydrocolloid possessing gelling, thickening, emulsifying, stabilizing, and encapsulating properties, with functional benefits such as hypolipidemic, hypoglycemic, appetite reducing, and gastroprotective effects3.
- Reduces total cholesterol, LDL cholesterol and triglycerides and increases HDL cholesterol:
- A reduction in the total cholesterol and triglycerides was observed among the subjects when treated with CGM3.
- Glactomannans from fenugreek was found to delay the absorption of LDL-cholesterol and triglycerides, whereas they promote the uptake of HDL-cholesterol inturn enhance the protective action of curcumin–galactomannoside complex against inflammatory cascade induced by oxidised LDL5.
- Helps to reduce alcohol mediated liver damage and supports healthy liver function markers
- Elevation in GGT (𝛾-glutamyl transferase) is a commonly used marker for chronic alcohol consumption and is an indicative of structural liver injury and hepatic microsomal induction. CGM group showed a significant reduction in GGT in many subjects.
- Elevated serum transaminases is generally considered as an indication of liver diseases supplementation of CGM was found to induce significant reduction in the elevated levels of serum transaminases8.
- Protection from inflammation:
- Upon CGM supplementation, CRP level was decreased by 27.3% from baseline. In the case of IL-6, there was 15.1% decrease in CGM group8
- Helps to maintain healthy glutathione levels:
- While the endogenous antioxidants GSH and SOD showed a significant enhancement, Ethanol associated depletion of GSH was reverted by 19.6% in CGM group8
Combination of CurQfen® + Longperin™
Longperin™ is standardised to have 10% piperine content. Piperine isolated from black pepper at a particular dosage was shown to enhance the bioavailability. So, addition of Longperin at a suitable concentration may enhance the bioavailability of curcuminoids. Long pepper is also an important Ayurvedic herb with antioxidant, detoxification and anticancer potential as shown by published studies.
We recommend consuming one capsule daily along with your meal.
 Vijayasteltar B. Liju, et. al, ‘Enhanced bioavailability and safety of curcumagalactomannosides as a dietary ingredient’, The Royal Society of Chemistry 2014
 Dinesh Kumar, et. al., ‘Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study’, Elsevier Ltd. 2016
 Subash Pandaran Sudheeran, MSc, et. al., ‘Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress A Randomized, Double-Blind, Placebo-Controlled Pilot Study’, Wolters Kluwer Health, Inc. 2016
 Marilyn S. Campbell, et. al., “Influence of enhanced bioavailable curcumin on obesity-associated cardiovascular disease risk factors and arterial function: A double blinded, randomized, controlled trial”, Fleenor Applied nutritional investigation, 0899-9007/© 2019 Elsevier Inc.
 Sangeeth Saji, et. al., ‘Curcumin–galactomannoside complex inhibits pathogenesis in Ox‑LDL‑challenged human peripheral blood mononuclear cells’, Springer International Publishing AG, part of Springer Nature 2018.
 Sibi P Ittiyavirah, Hema S, “Ameliorating demyelination effect of curqfen® in cuprizone induced mice model of multiple sclerosis”, Volume 7 Issue 1 – 2019 Pharm Pharmacol Int J.;7(1):17‒20
 Sunny A et. al., “Bioavailable curcumin alleviates lipopolysaccharide ‑induced neuroinflammation and improves cognition in experimental animals”, Volume XX, Issue XX, Month 2019 Pharmacognosy Magazine
 Naveen T. Krishnareddy, et. al., “A Novel Curcumin-Galactomannoside Complex Delivery System Improves Hepatic Function Markers in Chronic Alcoholics: A Double-Blinded, randomized, Placebo-Controlled Study”, Hindawi, BioMed Research International Volume 2018